loco

1. (colloquial) Crazy.Examples: "It's Cottontail Smith, and he's gone plumb loco!"; "Going loco down in Acapulco / If you stay too long / Yes, you'll be going loco down in Acapulco / The magic down there is so strong"; "Who you trying to get crazy with ése? Don't you know I'm loco?"colloquial

2. (Southwestern US) Intoxicated by eating locoweed.Synonyms: pea struckSouthwesternUS

1. (transitive) To poison with the loco plant; to affect with locoism.transitive

2. (transitive, colloquial, by extension) To render insane.Examples: "They say that he is locoed. The insane asylums of California contain many shepherds."broadlycolloquialtransitive

1. (rail transport, informal) A locomotive.Examples: "A locomotive is, next to a marine engine, the most sensitive thing man ever made; and No. .007, besides being sensitive, was new. The red paint was hardly dry on his spotless bumper-bar, his headlight shone like a fireman’s helmet, and his cab might have been a hard-wood-finish parlour. They had run him into the round-house after his trial—he had said good-bye to his best friend in the shops, the overhead travelling-crane—the big world was just outside; and the other locos were taking stock of him."; "Small boys in 1963 could have traction engines with real steam coming out of the funnel, and Old Western locos had flashing lights, hooters and cow-pushers."informal